Stretch marks, clinically known as striae distensae, are a common yet often distressing dermatological phenomenon. These skin irregularities predominantly result from the disruption of the skin's integrity due to excessive stretching of the dermis, leading to enduring morphological changes in the collagen elastic fibers. Commonly, the onset of stretch marks correlates with events or conditions that impose rapid skin stretching, such as significant weight gain or loss, pregnancy, puberty, or rapid muscle growth due to intensive physical training. Additionally, exogenous corticosteroids' overuse and conditions like Cushing's Syndrome, marked by increased cortisol levels, can predispose individuals to stretch marks. Currently, an array of therapeutic interventions has been explored to mitigate the aesthetic impact of stretch marks and augment skin elasticity. These range from minimally invasive treatments like chemical peels, needling, and non-ablative laser treatment, to more targeted therapies like carboxytherapy, Platelet-Rich Plasma (PRP), and radiofrequency. In our clinic, we have developed a treatment protocol to create a “controlled damage” in the dermis provoking neoangiogenesis and the production of endogenous collagen. The present case study scrutinizes this multimodal approach's effectiveness in treating striae rubrae on an 18-year-old female's thighs. The combined regimen entailed a chemical peel (comprising TCA 19%, malic, lactic, salicylic acids, and menthol), needling, carboxytherapy, and dermal polynucleotide injections. After alternating treatment sessions, significant improvement was observed in the visual appearance of the stretch marks, evidenced by a decrease in the size and number of scars after just one month. The patient expressed satisfaction with the results, endorsing our belief that this multimodal approach might offer a promising and efficient strategy in managing dermal scarring.